Abstract: Based on the background analysis of flood disaster risk management research, the theories of general distribution function and its entropy can be used to effectively describe and analyze the uncertainty information of flood disaster risk management system. Based on the mechanism of producing flood disaster risk and the integration methodology of risk management theory, water conservancy science, information science and intelligence science theories, the theoretical frame and its main contents of the comprehensive analysis theory based on general entropy and intelligence integration methodology for flood disaster risk management are presented, which consists of flood hazard analysis based on the general entropy and intelligence integration methodology, flood disaster vulnerability analysis based on the general entropy and intelligence integration methodology, flood disaster loss analysis and evaluation based on general entropy and intelligence integration methodology, and flood disaster risk decision-making analysis based on the general entropy and the intelligence integration methodology. The frame can also be applied to risk management of other disasters.