Abstract: The Agricultural Non-Point Source(AGNPS) pollution is widespread, random, and difficult to monitor and treat. It has been the focusing issue that models can be used to describe the transportation process, to calculate the pollutant load and to assess mitigation measures for AGNPS pollution in the field of the water environmental protection and treatment. This paper reviewed the research and application of the AGNPS model both at home and abroad, and describes the structure and mechanism. The results show that AGNPS model is acceptable. The simulation results in the hydrological years are better than those in the rainfall-runoff events. The simulation accuracies in runoff, sediment erosion, nitrogen and phosphorus load are different in the different research zones. It is realistic to assess the effect of the management measures and judge the critical zone. The grid-cell division, the sensitivity analysis and the parameters adjustment affect the model's accuracy to a larger extent. In view of the feature and the research status of AGNPS, the expectation and modification is put forward.