Abstract: In order to satisfy the requirements of water environment daily management on large-scale impounded river network, the Hydrology, Hydrodynamics, and Water Quality Model (DHQM) is designed based on the cross-integration of multiple methods. DHQM adopts a modular structure as well as one- and two-dimensional nesting frameworks. DHQM includes 5 parts: River runoff simulation, sluice scheduling simulation, river water quality simulation, local inflow and river pollution load estimation, and water quality real-time correction. DHQM demonstrates a fair data robustness and flexibility in application, which boosts its applicability for the real-time early warning and regulation of water environments as well as for quantifying the hydrological and environmental effects of dams and sluices.