Abstract: The problem of non-point source pollution has become an emerging issue associated with the implementation of effective control of point source pollution. The use of nonpoint pollution source models as an effective means of controlling pollution can provide valuable insight into the process of formation of point source pollution, and the subsequent migration and transformation, as well as pollutant loadings. However, the major challenge in single model approach to a catchment is the problem of uncertainty in pollution modeling. The multi-model approach has been successfully applied to hydrological modeling for dealing with uncertainty. Based on the analysis of similarity between hydrological models and non-point source pollution models, a multi-model approach for modeling non-point source pollution is proposed. The basic idea, key obstacles and challenges in the approach are also discussed.