Abstract: The safety stockpile of nuclear waste,the forecast and control of groundwater contamination and many other key problems demand to research the groundwater solute transport in the large-scale fractured rock.The scale effect of groundwater solute transfer in fractured rock is a great challenge for the research. The multi-scale conceptual model and its physical and mathematical simulating method of groundwater solute transport in fractured rock are introduced,and the relation of simulating scale and surveying scale,forecasting scale,fractured medium scale and the fractal characteristic of scale dependent are also discussed.