Abstract: This paper presents a two-dimensional unsteady flow model(RBFVM22D),which is based on the finite volume method combined with unstructured triangle and quadrilateral grids in the Yangtze River in Jiangsu province.The simultaneous hydrodynamic,water quality and remote sensing data are used to calibrate and verify the model.The results agreed well with the field data.Based on the investigation of the water quality,pollution sources and stability of the river bank,the main pollutant mixed belts in generalized pollutint and the relationship between the area of the belts and the discharged pollutants are computed.The water quality situation in the water supply place is analyzed and the suitable pollution control measure is given.