Abstract: In order to optimize the operation mode of reservoir groups in the Middle and Lower of the Yellow River, and to give full play to the advantages and potential of the water-sediment joint regulation of reservoir groups and river channel, taking the reservoir groups and river channel in the Middle and Lower of the Yellow River as the research objects, the method of joint dynamic regulation of reservoir groups and river channel was studied, and the mutual feedback index, mutual feedback model, regulation principle and application of joint dynamic regulation of reservoir groups and river channel were constructed. In this way, we developed a water-sediment joint regulation simulation model of reservoir groups and river channel, and analyzed regulation effects of the current project in the Middle and Lower of the Yellow River. The results show that under the scenario of 800 million to 300 million tons of incoming sediment of the Yellow River in the future, the water-sediment joint dynamic regulation of reservoir groups and river channel comprehensively takes into account the reduction of siltation in the reservoir and the river course, and can extend the sediment retention period of the reservoir by 4 to 9 years. In a relatively long period of time, the coordination degree of the water-sediment relationship entering the downstream has been improved. The total siltation of the downstream river channel is less, and the minimum bank-full discharge of the river channel has increased by 200—250 m³/s.