Abstract: In the last 70 years, China has made great achievements in the treatment of the Huaihe River basin. Now the main stream of the middle and lower reaches of Huaihe River and the Hongzehu Lake have become the key areas for further treatment. This paper systematically sorts out the main contradiction changes in the treatment of the Huaihe river basin in the new period, from the perspective of strategic status improvement of the river basin, economic and social development, evolution of natural environment and changes in water issues. The strategic thinking and suggestions for comprehensive treatment of the middle and lower reaches of the Huaihe River basin are also put forward, from the aspects of basic research on water and sediment, reveal of targeted problems, restructuration of rivers and lakes, and comprehensive treatment measures. This paper also introduces the contents and technical methods of further research on the evolution and treatment of the main stream of Huaihe River and the Hongzehu Lake, as well as the preliminary research results and conclusions, from the following four aspects: the revolution law of rainfall and flood in the main stream and tributaries, the characteristics of sediment in the main stream of Huaihe River and the Hongzehu Lake and their variation law, the present situation and the flood control effect and coordination of the planned project, and the proposal for combination scheme of engineering measures. This paper can provide a reference for the planning and designing of the Huaihe River basin treatment in the new period.