Abstract: Recently,there are more and more large-scale water engineering construction projects in the Pearl River Estuary,such as waterway regulation,bridge engineering and port construction. The importance of safety of hydraulic structures and sensitivity to typhoon wave damage are one of the key factors of large-scale projects. In this paper,the influence of extreme weather conditions on the design wave parameters of artificial island at the junction of Hong Kong-Zhuhai-Macao Bridge is analyzed and calculated by using typhoon wave numerical model. Firstly,the landing typhoon data affecting the coastal areas of Guangdong Province from 1949 to 2014 are analyzed,and the parameters of typhoon pressure drop and maximum landing wind speed 300-year event in Pearl River Estuary are analyzed by stochastic model. Then,the numerical model of typhoon wave in Pearl River Estuary waters is established. Finally,the unfavorable landing typhoon track is selected,and the wave parameters of east and west artificial islands in the Pearl River Estuary under extreme weather conditions are calculated by using the combination of typhoon parameters 300-year event,and the original design wave elements are reviewed. It can provide new ideas and research methods for the design of other ocean engineering projects.