Abstract: To address the current water scarcity situation, a novel multi-objective optimization framework was proposed for the management of existing engineering measures related to river multi-damming impoundment and strategies for groundwater abstraction in the Dagu River basin. The optimization framework integrates a calibrated numerical model with a conceptualized river package to simulate the interaction between the Dagu River and groundwater due to river impoundment, thus focusing on the trade-off between minimizing the extent of seawater intrusion and river seepage and maximizing allowable groundwater abstraction. Subsequently, the NSGA-Ⅱ was employed to explore Pareto-optimal solutions affected by varying climatic conditions. The results indicate that in order to mitigate the seawater intrusion, the impound river water level behind the dam located near the areas affected by prolonged insufficient precipitation should be increased by a minimum of 0.5—1.5 m, while lowering the river water level behind the other dams by approximately 1 m. Under the constraint of restricting groundwater abstraction, the annual groundwater abstraction in the four county-level administrative subdomains should be modified by 1.2—1.5 million m³ or more, during periods of lower precipitation compared with higher, in the float. The optimization framework and regulation strategies presented here may be implemented in other coastal aquifers subjected to severe anthropogenic activities.