Abstract: The turbulent structure and the vertical distribution of the velocity of sediment-laden flow would be effected by the sediment condition including sediment particles' diameters and concentration. In this paper,the MicroADV is used to measure the mean velocity distribution of sediment-laden flow. It analyzes the influence of interaction between the sediment particles and flow on the distribution of the velocity of the flow with the different sediment condition and flow intensity. By verifying the application of the existing distribution formula with the experimental data,a new formula of exponential of the velocity distribution is proposed,at the same time,the variational law of coefficient(k)and index(m)in the new formula with the sediment concentration(s),the diameter of particles(d)and the hydraulic condition is analyzed.It is concluded that the k increases with the increasing sediment concentration,the hydraulic condition and the diameter of particles.However,the m decreases with the increasing diameter of particles,and increases with the increasing sediment concentration.