Abstract: In this paper,the spatial variation of permeability with depth in a formation of the fractured sandstone mudstone media is analyzed The permeability value is represented by unit absorption ω obtained from the packer permeability test.The variability of permeability is so significant that the value of ω spans 3 to 4 orders of magnitude at different depths By taking mean value of log ω at different depths,the pattern of permeability versus relative depth is easy to discover We found that the variation of permeability with relative depth obey the exponent ial law; After subtract ing the linear trend of log ω with depth,the residual of log ω can be well correlated with the distribution of mudstones In addition,the linear trend of log ω with depth is caused by the fractured sandstone.The spat ial structure of permeability in the study area is clearly and quantitatively characterized by the methods proposed in this paper,which can be utilized for researches on similar studies areas.